GREEN-SYNTHESIZED TITANIUM OXIDE NANOPARTICLE FROM CASSIA FISTULA SEEDS: A NOVEL APPROACH TO ANTIOXIDANT, ANTIDIABETIC AND ANTICARIOGENIC ACTIVITIES

Abstract

Titanium oxide nanoparticles were synthesized using the seed of cassia fistula which was used to determine the alpha amylase, alpha glucosidase inhibition assay and antioxidant activities are examined by DPPH (diphenyl-2 picrylhydrozyl) method. The characterization of synthesized Titanium oxide nanoparticles were confirmed by the UV- visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM), Energy dispersive X-ray (EDX). The UV- visible spectroscopy was used to examined the Titanium oxide nanoparticles and the peak range was observed at 369.1nm. The FTIR was used to analyses the functional group present in the seed extract and Titanium nanoparticle. The SEM analysis showed the spherical and cubic shape of the synthesized Titanium oxide nanoparticles. The element composition of the synthesized Titanium oxide nanoparticle is determined by EDX analysis. The crystalline nature of the Titanium oxide nanoparticle was analyzed by using XRD technique. The result shows that the seeds titanium oxide NPs exhibits inhibitory effect on alpha amylase (69.64%), inhibitory effect on alpha glucosidase (71.57%) by using the standard acarbose drug. The antioxidant activites by DPPH method shows the activity of seeds with Titanium oxide NPs (73.21%) by using the standard of ascorbic acid. The analysis showed a better inhibition against Streptococcus mutans, Streptococcus salivaryus, Streptococcus sobrinus and Staphylococcus aureus. Therefore, it is suggested that the synthesized Titanium oxide nanoparticles using seeds extract of Cassia fistula as the good yield of inhibitor for diabetes and cariogenic.

Author

Suganya C, Balachandran C, Kamaraj B, Logapriyan P B, Selvamoorthi k